If you follow the CDC present recommendation schedule Your Child will have: 6 Inoculations of 3 different diseases. Diphtheria, Tetanus, and Pertussis.
As of this year the CDC recommends that all adults get the TDaP vaccine every ten years. If you live to be 78 you will have a total of 12 inoculations for a total of 36 encounters.
The CDC Guide to Vaccine Contraindications and Precautions has many notes on TDaP inoculation, so we will have to do a separate presentation on that.
DTaP (Daptacel): Aluminum Phosphate, Ammonium Sulfate, Casamino Acid, Dimethyl-beta-cyclodextrin, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol
DTaP (Infanrix): Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldyde, 2-Phenoxyethanol, Polysorbate 80
DTap (Tripedia): Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sodium Phosphate, Trace Thimerosal
For More Information Please Click: Read More
- 2-Phenoxyethanol: A preservative. For full information see: http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_00d2/0901b803800d29f2.pdf?filepath=productsafety/pdfs/noreg/233-00323.pdf&fromPage=GetDoc
- Aluminum Hydroxide: Is a naturally occurring mineral. It is an antacid. From drugs . com, Aluminum hydroxide may pass into breast milk and could harm a nursing baby. Aluminum hydroxide side effects: severe stomach pain or constipation. Bloody, black, or tarry stools. Coughing up blood that looks like coffee grounds. Pain when you urinate. Extreme drowsiness, tired, loss of appetite, and muscle weakness.
- Aluminum Phosphate: Aluminum phosphate mixture is a slow acting antacid used similarly to aluminum hydroxide mixture. Unlike aluminum hydroxide, it does not interfere with phosphate absorption and is used when a high-phosphporus diet cannot be maintained or if there is diarrhea or a deficiency of pancreatic juice. It is also used as an adjuvant in adsorbed vaccines. The mixture is given in doses of 5 to 15 ml and dried aluminum phosphate in doses of 400 to 800 mg.
- Aluminum Potassium Sulfate: An astringent and styptic
- Ammonium Sulfate: An astringent
- Astringent: Drawing together, constricting, binding. An agent that has a constricting or binding effect.
- Bovine Extract: Pert. To cattle, derived from cattle
- Casamino Acid: is a hydrochloric acid hydrolysate of casein.
- Formaldehyde: A colorless, pungent, irritant gas commonly made by oxidation of methyl alcohol, the simplest member of the aldehyde group. An aqueous solution of 37% formaldehyde (formalin) is used as a preservative. This CHEMICAL has been SHOWN TO BE CARCINOGENIC in certain animals and may be carcinogenic in HUMANS.
- Gelatin: Is a protein made from animal products
- Glutaraldhyde: Is a colorless, oily, liquid chemical with a pungent odor. Used for a number of reasons: sterlilant, tanning agent, antimicrobial, disinfectant, and preservative
- Side Note: Please See OSHA’s publication on Glutaraldeyde (Highlight: The most serious adverse health effect documented among employees exposed to glutaraldehyde vapor is asthma.), : https://www.osha.gov/Publications/glutaraldehyde.pdf See also: http://www.inchem.org/documents/sids/sids/111308.pdf
- Polysorbate 80: is a surfactant and emulsifier used in cleaners and personal care products. It is also called Tween 80.
- Sodium Phosphate: Is a type of Salt. Phosphorus is a naturally occurring substance that is important in every cell in the body. The majority of phosphorus in the body is found in the bones. The potassium and sodium salt forms of phosphorus are called phosphates.
- you should not take potassium phosphate and sodium phosphate if you have: high levels of potassium in your body, high levels of phosphorus in your body, infected phosphate stones, or severe kidney disease. Before taking potassium phosphate and sodium phosphate, tell your doctor if you have Addison's disease, a bowel obstruction, heart disease, high blood pressure, kidney disease, liver disease or cirrhosis, swelling or water retention, high levels of sodium in your body, low levels of calcium in your body, hypoparathyroidism, pancreatitis, or rickets.
- IN Jan of 2014, the FDA issued a Safety Warning for Sodium Phosphate. If You were to use an Over-the-counter sodium phosphate product to treat constipation: going over 1 dose in a 24 hour period can cause harm to kidneys, heart, and even death.
- Thimerosal: An organic mercurial antiseptic used topically and as a preservative in pharmaceutical preparations.
- Red Line In Taber’s Caution: Children and pregnant women should not be given immune globulin or vaccinations that use thimerosal as a preservative.
Daptacel Description: DAPTACEL vaccine is a sterile isotonic suspension of pertussis antigens and diphtheria and tetanus toxoids adsorbed on aluminum phosphate, for intramuscular injection. Each 0.5 mL dose contains 15 Lf diphtheria toxoid, 5 Lf tetanus toxoid and acellular pertussis antigens [10 mcg detoxified pertussis toxin (PT), 5 mcg filamentous hemagglutinin (FHA), 3 mcg 277 pertactin (PRN), and 5 mcg fimbriae types 2 and 3 (FIM)].
Other ingredients per 0.5 mL dose include 1.5 mg aluminum phosphate (0.33 mg of aluminum) as the adjuvant, ≤5 mcg residual formaldehyde, <50 ng residual glutaraldehyde and 3.3 mg (0.6% 280 v/v) 2-phenoxyethanol (not as a preservative). The acellular pertussis vaccine components are produced from Bordetella pertussis cultures grown in Stainer-Scholte medium (2) modified by the addition of casamino acids and dimethyl-beta-cyclodextrin. PT, FHA and PRN are isolated separately from the supernatant culture medium. The FIM components are extracted and co-purified from the bacterial cells. The pertussis antigens are purified by sequential filtration, salt-precipitation, ultrafiltration and chromatography. PT is detoxified with glutaraldehyde. FHA is treated with formaldehyde, and the residual aldehydes are removed by ultrafiltration. The individual antigens are adsorbed separately onto aluminum phosphate. Corynebacterium diphtheriae is grown in modified Mueller’s growth medium. After purification by ammonium sulfate fractionation, diphtheria toxin is detoxified with formaldehyde and diafiltered. Clostridium tetani is grown in modified Mueller-Miller casamino acid medium without beef heart infusion. Tetanus toxin is detoxified with formaldehyde and purified by ammonium sulfate fractionation and diafiltration. Diphtheria and tetanus toxoids are individually adsorbed onto aluminum phosphate. The adsorbed diphtheria, tetanus and acellular pertussis components are combined with aluminum phosphate (as adjuvant), 2-phenoxyethanol (not as a preservative) and water for injection.
DTap Infanrix Description: INFANRIX (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) is a noninfectious, sterile vaccine for intramuscular administration. Each 0.5-mL dose is formulated to contain 25 Lf of diphtheria toxoid, 10 Lf of tetanus toxoid, 25 mcg of inactivated pertussis toxin (PT), 25 mcg of filamentous hemagglutinin (FHA), and 8 mcg of pertactin (69 kiloDalton outer membrane protein). The diphtheria toxin is produced by growing Corynebacterium diphtheriae in Fenton medium containing a bovine extract. Tetanus toxin is produced by growing Clostridium tetani in a modified Latham medium derived from bovine casein. The bovine materials used in these extracts are sourced from countries which the United States Department of Agriculture (USDA) has determined neither have nor present an undue risk for bovine spongiform encephalopathy (BSE). Both toxins are detoxified with formaldehyde, concentrated by ultrafiltration, and purified by precipitation, dialysis, and sterile filtration. The acellular pertussis antigens (PT, FHA, and pertactin) are isolated from Bordetella pertussis culture grown in modified Stainer-Scholte liquid medium. PT and FHA are isolated from the fermentation broth; pertactin is extracted from the cells by heat treatment and flocculation. The antigens are purified in successive chromatographic and precipitation steps. PT is detoxified using glutaraldehyde and formaldehyde. FHA and pertactin are treated with formaldehyde.
Diphtheria and tetanus toxoids and pertussis antigens (PT, FHA, and pertactin) are individually adsorbed onto aluminum hydroxide. Diphtheria and tetanus toxoid potency is determined by measuring the amount of neutralizing antitoxin in previously immunized guinea pigs. The potency of the acellular pertussis components (PT, FHA, and pertactin) is determined by enzyme-linked immunosorbent assay (ELISA) on sera from previously immunized mice.
Each 0.5-mL dose contains aluminum hydroxide as adjuvant (not more than 0.625 mg aluminum by assay) and 4.5 mg of sodium chloride. Each dose also contains ≤100 mcg of residual formaldehyde and ≤100 mcg of polysorbate 80 (Tween 80).
DTaP Tripedia Description: Tripedia®, Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed (DTaP), for intramuscular use, is a sterile preparation of diphtheria and tetanus toxoids adsorbed, with acellular pertussis vaccine in an isotonic sodium chloride solution containing sodium phosphate to control pH. After shaking, the vaccine is a homogeneous white suspension. Tripedia vaccine is distributed by Sanofi Pasteur Inc. Corynebacterium diphtheriae cultures are grown in a modified Mueller and Miller medium Clostridium tetani cultures are grown in a peptone-based medium containing a bovine extract. The meat used in this medium is US sourced. Both toxins are detoxified with formaldehyde. The detoxified materials are then separately purified by serial ammonium sulfate fractionation and diafiltration. The acellular pertussis vaccine components are isolated from culture fluids of Phase 1 Bordetella pertussis grown in a modified Stainer-Scholte medium. After purification by salt precipitation, ultracentrifugation, and ultrafiltration, preparations containing varying amounts of both pertussis toxin (PT) and filamentous hemagglutin in (FHA) are combined to obtain a 1:1 ratio and treated with formaldehyde to inactivate PT. The diphtheria and tetanus toxoids are adsorbed using aluminum potassium sulfate (alum). The adsorbed toxoids are combined with acellular pertussis concentrate, and diluted to a final volume using sterile phosphate-buffered physiological saline. Each 0.5 mL dose is formulated to contain 6.7 Lf of diphtheria toxoid and 5 Lf of tetanus toxoid (both toxoids induce at least 2 units of antitoxin per mL in the guinea pig potency test), and 46.8 µg of pertussis antigens. This is represented in the final vaccine as approximately 23.4 µg of inactivated PT and 23.4 µg of FHA. The inactivated acellular pertussis component contributes not more than 50 endotoxin units to the endotoxin content of 1 mL of DTaP. The potency of the pertussis components is evaluated by measuring the antibody response to PT and FHA in immunized mice using an ELISA system.
The vaccine is formulated without preservatives, but contains a trace amount of thimerosal [(mercury derivative), (≤0.3 µg mercury/dose)] from the manufacturing process. Each 0.5 mL dose also contains, by assay, not more than 0.170 mg of aluminum and not more than 100 µg (0.02%) of residual formaldehyde. The vaccine contains gelatin and polysorbate 80 (Tween-80), which are used in the production of the pertussis concentrate
****Please see part one for Special Notes and Listed Side-effects in the Vaccine Inserts
Lf means: Lf dose: the limes flocculation dose of diphtheria toxin, the smallest amount of toxin that, when mixed with one unit of antitoxin, yields the most rapid flocculation in the Ramon test (in vitro); in general, the Lf dose is slightly less than the Lr dose.
Package Insert Link: Daptacel: http://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm103037.pdf
Package Insert Link: Infanrix: https://www.gsksource.com/gskprm/htdocs/documents/INFANRIX.PDF
Package Insert Link: Tripedia: http://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm101580.pdf
Other source information: http://www.drugs.com/mtm/potassium-phosphate-and-sodium-phosphate.html